Research on the Effectiveness of Borrelogen

Borrelia burgdorferi antigen release stimulation by nutraceutical formula as determined by Lyme Urine Antigen Testing (LUAT)

(Presented by Dr. David A. Jernigan, at the 1999 International Tick-Borne Diseases Conference, New York City, New York)

Abstract

It is understood that antigens are the cause of numerous sensitivities resulting in much of the symptomatology experienced in chronic illness. This clinical study was restricted to determining whether Borrelia burgdorferi specific antigen (Literally the dead pieces of Bb) could be purged from circulation by the use of a nutraceutical formula called Borrelogen. The results are very preliminary as more research is needed to rule out physiological interference. LUAT assay was utilized to determine antigen release after 68 subjects used the nutraceutical for one week. Results revealed 73% of the subjects released specific antigen to the degree of being considered positive or highly positive by LUAT. (Only seventeen of the 68 subjects were tested by Lyme Western Blot IgM/IgG prior to starting Borrelogen. All seventeen subjects were either Equivocal or Positive via this serological assay.) This study in itself cannot be used to make definitive statements about the efficacy of Borrelogen, only that an antigen was released from whatever mechanism. Note: IGeneX is not in any way endorsing this nutraceutical, nor is IGeneX associated in any way with Jernigan Nutraceuticals,

Inc. IGeneX was blinded to the use of the nutraceutical and only performed the testing procedure. True research seeks to find the truth in an unbiased manner for the betterment of mankind.

Introduction

Bacteria contain many particulate and soluble antigens that evoke strong, often lasting immune responses, both humoral and cellular.193 According to Stedman’s Medical Dictionary, an antigen (allergen) is any substance that, as a result of coming into contact with appropriate tissues, induces a state of sensitivity.194 Antigens are understood to cause many of the symptoms experienced by Lyme Disease sufferers. It would stand to reason that decreasing the antigen load on the body would correspondingly decrease the number and severity of symptoms. A proprietary nutraceutical formulation was developed in 1998 to specifically target the functional release of spirochetal antigen from the tissues of the body. The historical and pharmacognostic data of the individual plant-based extracts reveal very low toxicity, while being functionally beneficial in many ways to the body. The research presented here was performed as a clinical study to aid in our understanding of the potential effectiveness of the nutraceutical formula Borrelogen. Lyme Urine Antigen Testing (LUAT) was chosen as a viable determinant due to its specificity to Borrelia burgdorferi antigens seen as a result of a release of antigen from an appropriately applied therapy. Because the body will, as a natural process, release Lyme specific antigen in about 30% of untreated cases, the nutraceutical formula was tested to see if the body could be stimulated to release a greater amount of antigen, with a higher percentage of positive LUATs. A nutraceutical is defined as a plant-based remedy that is specifically formulated to target specific body dysfunctions.195

Methods

Participants in this study were pre-selected based on positive Borrelia burgdorferi screening, using Bio-Resonance Scanning assay. The group consisted of 68 people residing in a non-endemic area of the United States. All were suffering from a range of 3 to 44 chronic problems based on a 55- question Lyme Disease symptom questionnaire. Lyme Urine Antigen Testing (LUAT) was utilized to monitor the release of antigen. LUAT testing is an antigen capture assay specific to detection of low levels of antigen, in spite of the presence of other proteins. The antibody being used in this antigen capture is a unique polyclonal antibody that is specific for the 31 kDa (OpsA), 34 kDa (OpsB), 39 kDa, and 93 kDa antigens of Borrelia burgdorferi. This assay appears to be very specific to these antigens with a reported false positive rate of less than 1% in a study of 408 controls.196 The reference range of a LUAT is based on P-values or confidence levels. Antigen levels reported as 32 ng/ml have a 95% confidence level of being positive and distinguishable from a negative population.197 A LUAT is a highly controlled and reproducible assay which is used in conjunction with patient history, symptoms and serum panels. The nice thing about LUAT assay is that it is positive throughout all three stages of infection: early, which is said to be <60 days (which is before you normally can get a seropositive result); second stage, which is defined as 60 – 360 days; and the third stage, >360 days.198

Results

Reporting only the highest score of the three-day urine collection, the majority of positive LUATs scored over 100 ng/ml. Out of the 68 LUATs, performed 44 were reported as positive or highly positive, while there were 4 borderline, and 18 negative results. The total percentage of positive scores was 73%. When the nutraceutical formula was used instead of prescription antibiotics, the majority of positive LUATs were reported over 100 ng/ml, and as high as >400 ng/ml. Although a score of >400 does not indicate that a patient is more highly infected than a score of >45, it does indicate a high rate of antigen release which can only benefit the patient. An interesting side note: only 17 of these 68 cases were also tested by Lyme Western Blot IgM/IgG prior to taking the Borrelogen. All 17 subjects tested as positive or equivocal by Lyme Western Blot.

Conclusion

Based on this study, it appears that this nutraceutical formula does indeed stimulate the purging of Borrelia burgdorferi antigens from the body. This antigen-detox can only be seen as a good thing as these antigens, when circulating throughout the body, cause a multitude of systemic sensitivities, which in turn causes increased suffering in the patient. An infected person does not release antigens daily or uniformly.199 It is significant that, 73% of the time, a high release of antigen was stimulated while using this nutraceutical. Further research must be performed to determine if a negative control group on the same protocol would yield a similar effect. However, based on positive patient symptomatic response and clinical observations, we are encouraged that this botanical formula may effectively stimulate and increase the tissue elimination of deleterious antigen via the urine. Further research may also result in increased probability of highly positive Lyme Urine Antigen Test confirmations.

Interference studies performed by IGeneX lab confirmed that Borrelogen does not cause a false positive LUAT when negative patient urines were spiked in various concentrations. This in vitro assay does not, however, effectively rule out the possibility of in vivo interference.

192 Glenn T. Shwaery, G. TPh. D., 99G-0905m 1999 Toxikon Corp. Sponsored by International Nutraceutical Research Group.

193 Coltran, Kumar, Robbins. Robbins Pathological Basis of Disease. 4th Edition; p.335. 194 Stedman’s Medical Dictionary. 25th Ed. Williams & Wilkins.
195 Journal of Nutraceuticals and Functional Foods, 1994.
196 Journal of Nutraceuticals and Functional Foods, 1994.

197 Journal of Nutraceuticals and Functional Foods, 1994.
198 Calllister SM, Schell RF. Laboratory Serodiagnosis of Lyme Borreliosis. J Spirochetal Tick-

borne Inf 1998; 1:21.
199 Harris NS. IGeneX Reference Laboratory Guide, 1998; 4.

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Lyme Disease Treated as a Metabolic Syndrome

Conventional medicine still has Lyme disease pegged as a bacteria problem. In reality, it is a disease rooted in inherited and acquired disturbances in many of the primary metabolic pathways in the body, setting the stage the for over-population of the various microbes now associated with Lyme disease. In other words, it is a condition predicated more by a person's biochemistry than by the presence of specific bacteria, although helping the body bring down the over-population of bacteria through frequency-specific treatments is still very important. 

As noted by renowned author, and scientist, Otto Wolff, M.D. in his book on infectious disease: 

"Antibiotic therapy, since it is concerned only with the sensitivity of the pathogen (bacteria), disregards the significance of the location of the infection. The affected organ tissue is obviously the weak link in the body's resistance, and if this is not taken into account, then underlying functional disorder remains untreated. The stage is thus set for recurrent, chronic inflammations of far more severe illnesses of the affected functional system."

Changing Mindset Changes Results

Consider the illness diabetes, an illness that may seem obviously caused by excessive sugar consumption. According to the Department of Health and Human Services, the average American consumes almost 152 pounds of sugar every year, in 1970 it was still 123 pounds, so the average American has literally been been eating a ton of sugar every 13 years! That is 2000 pounds of pure sugar. Yet according to the Centers for Disease Control, the CDC, only 9.4% of Americans have diabetes. 

As counter-intuitive as it may seem, sugar by itself is not the ultimate cause of diabetes. It should be apparent that the breakdown in a person's metabolic/biochemical pathways leads to the condition known as diabetes. With this in mind, bacteria by itself is not the true cause of Lyme disease, any more than sugar by itself is the cause of diabetes. 

I am a firm believer in what I have seen in thousands of cases, as well as from the publications of the often quoted cell pathologist, R. Virchow, holding that, "knowledge of the bacteria, necessary as it is for a full understanding of the origination of the disease process, still by no means explains the process itself (metabolic disturbances), nor renders a distinct investigation of it superfluous."

Most People are on the Verge of Becoming Sick 

An estimated 133 million or 45% of Americans suffer from a chronic illness. Another 45 million suffer from mental illness. The CDC reports that 48 million get sick every year from foodborne infections. By some estimates there are 300,000 new cases of Lyme disease every year, although this number is likely much larger due to poor reporting and testing.

It would seem that illness is just our lot in life, especially to those that believe there is nothing beyond pharmaceuticals and their drug-induced remissions. Thankfully it is evident to many scientists and forward-thinking doctors that is not the case in Lyme disease or other illnesses. 

Leading scientists and doctors feel that there are many more people, likely a large segment of the world population that have the various bacteria that make up Lyme disease, yet never experience any of the symptoms. As prevalent as Lyme disease may seem, the vast majority of people with the "infection" do not have the disease. Scientists and research-minded doctors are pursuing this situation to identify what those who are affected are missing, compared to the healthy ones that do not manifest the disease.

Illness is not our lot in life, if we shift the treatment goals from the antiquated and disastrous antibiotic and symptom-suppressing methods, to the latest treatment that seeks to restore the optimum metabolic pathways through genetic and epigenetic testing and modifications to the expression of these key predisposing factors in the development of disease.  

We know intuitively if we take care of ourselves, eating well, exercising, and living well, that we feel better and get sick less often. Take that concept much further and imagine doctors striving to add to those things, and actually identify all the locations your metabolic pathways are blocked. These biochemical pathways control your mood, emotions, cognition, the ability to breakdown and eliminate toxins, the overgrowth of microbes, wake and sleep cycles, arousal and ability to rest your mind - everything!

Backtracking Illness to its Core Metabolic Pathway Issues

With the unveiling of the Genome Project by the international scientific community in 2003, the sad realization hit the world of illness like a ton of bricks, that most illnesses would not be cured by means of gene manipulation. Thankfully the scientific community kept researching and in 2010 joyfully announced the results of the ENCODE Project, the discovery of 4 million epigenetic switches that controlled the expression of the DNA, and were ultimately regulating every biochemical metabolic process in the body. 

Finally, the true underlying predisposing factors to every illness known to mankind had been found. The next step was to develop technologies to access the software that controls those switches and ultimately controls your health.

The reality is rapidly becoming clear that the future of medicine will be tapping into the body's energetic software, literally plugging into the bioinformation system through energetic testing, much like your car mechanic plugs into your car's computer to diagnose problems in the engine.

Much of the energetic testing research has been done by clinicians, many who are Doctors of Chiropractic Medicine, since by training and philosophy their treatment goal has always been to free up or restore the self-organizing, self-healing mechanisms throughout the entire human organism. 

These leading edge scientists were, and still are often persecuted by mainstream medicine and governmental regulatory agencies. Thankfully these energetic discoveries are now being given credence, albeit slowly. 

Indeed, all of the energetic testing systems of the world have advanced our knowledge of and ability to access the bioinformation system of the body including but not limited to: acupuncture, applied kinesiology, clinical kinesiology, electrodermal testing, microcurrent testing, and now BioResonance Scanning, and it's latest advancement, Fractal Frequency Modulation.

Backtracking Lyme Bacterial Overgrowth to its Primary Causes in the Metabolic Pathways

The EM signatures of pathology of any type are encoded in the bioinformation system of the body. Electromagnetic sentences are being posed to the body in real-time testing, such as BioResonance Scanning (BRS) and Fractal Frequency Modulation (FrFM) that appear to be able to detect the pathology in question, and through sequenced testing backtrack the pathology to its primary metabolic points of origin. 

Once the key pathways are identified, each step in the biochemical pathways can be tested to determine where the blockages are occurring, (see the example of these pathways in the figure below) likely from epigenetic-induced enzyme deficiencies as well as key mineral and nutrient deficiencies, which may also be from other remote pathway disturbances. 

Having identified what the interference is, more specific sequenced testing can then be done to identify the corrective treatment that is needed by the body to cause the epigenetic switches to orient themselves to correctly regulate that point in the pathway, possibly for the first time in the person's life. 

It is fascinating to see that often all the body needed was a specific, one-time application of a bioenergetic therapeutic input to open up the pathway, as manifested by the rapid disappearance of the EM signature of pathology and improvement of the person's symptoms.

As each of the predisposing metabolic pathways are cleared, the bacterial frequencies disappear, seeming to fade into the normal microbial collective that is always present, even in a healthy subject.

It appears that treating to kill the bacteria, whether with antibiotics or natural remedies is misguided at best and at the worst further disrupts the metabolic pathways leading to the development of chronic illness and increased suffering. 

Call Hansa Center today to finally identify the real reasons you are sick. 

For over 20 years the Hansa Center for Optimum Health, in Wichita, Kansas has specialized in the restoration of health for people with previously unresponsive and chronic illnesses of virtually all types. Over 85% of people come from other states and countries. If you have done everything you and your doctor know to do and are still struggling, contact our wonderful Patient Care Coordinator, Kara, at patientcare@hansacenter.com, for information on the exciting new treatments we have developed at the Hansa Center for Optimum Health. For additional info, visit our website at www.HansaCenter.com.

This article is for educational purposes. Before implementing any supplements/remedies always consult with your healthcare professional. Due to the complexity of the human condition there remains the possibility of symptoms getting worse. Again, discuss the ideas presented here with your health care professional before beginning, and stop, or get support, if your condition worsens. This information is not intended to treat, cure, diagnose, or mitigate any disease or illness, and has not been evaluated by the FDA. The Hansa Center does not treat named diseases, but seeks to restore the body's optimum structural and functional integrity so that the body can rapidly heal itself. 

*Due to the exhaustive time spent per day with each patient, and poor repayment history of insurance companies, we unfortunately cannot accept insurance assignment. We do participate in Care Credit, and accept all major credit cards. We will gladly accept insurance when our elected officials revamp the health insurance industry to cover all results-based care. We encourage you to vote with this in mind. Please call 316-686-5900 ext. 1, for current pricing for our economically-priced, All-inclusive 2-3 weeks intensive packages of care.

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Correcting Mast Cell Activation Syndrome -Histamine Intolerance - Mastocytosis

Do you envy people who can eat anything they want, wear perfume/cologne, and are exposed to daily scents without reacting? The luxury of having the ability to think clearly, eat anything, be pain free, and be essentially symptom free without having to take something is a pipe-dream you may be thinking.  I am here to tell you it is now possible, but like most complicated illnesses it requires sensitive testing and tailored treatments.

Everyone has heard of allergies, histamine, and especially antihistamines, but less people have heard of mast cells. If you have heard of mast cells then you likely know that you are in trouble and have been surfing the internet looking for deeper answers because your life is likely a hypersensitive mess, not just physically, but emotionally, and mentally! Two family members were born with this problem and after 25 years of treating some of the toughest cases and researching real solutions, I feel like I know a thing or two about the regulation of histamine and have a passion for helping people move way beyond just symptom relief. My own wife had such high blood histamine levels causing very severe issues for years that I had worked and worked on, trying one treatment after another until finally hitting on a new way to treat it and all of her symptoms have resolved.

If you are reading this, you likely know what you have is not ever going away with simple antihistamine drugs or by taking DAO supplements, which can help the symptoms, but are just masking or bypassing the real problems and are not offering lasting correction.

Like so many other serious illnesses, there is no at-home protocol and you must be tested and treated in the clinic. Even then, no two people are the same or respond the same way. You have to correct the many possible combinations of problems. If you would like to be tested and treated at the Hansa Center for Optimum Health, in Wichita, KS, call today at the number listed at the bottom of this article.

Difference and Similarities

Mast Cell Activation Syndrome, Histamine Intolerance, and Mastocytosis all have unique causes and yet share many of the same symptoms.

Mast cells are found in connective tissue, containing small granules (small little packets) that are rich in histamine.  The most well known is histamine, but others include leukotrienes (which also play a role in allergies), serotonin, ATP (your body’s primary energy currency), inflammatory cytokines such as TNF-alpha and interleukin-4, reactive oxygen species (like H2O2, which help kill off foreign invaders), and enzymes like tryptase.

Mast cells just carry all these compounds around in the bloodstream, selectively releasing their contents when triggered. Triggers include binding with two or more IgE molecules (the “hypersensitivity” immunoglobulin, characteristic of true allergies), physical injury, or pathogenic microbes. When mast cells release all their contents at once, that’s called anaphylaxis, and it can be life-threatening.

Mast Cell Diseases

Histamine Intolerance is when a person cannot efficiently break down histamine from the body, as well as naturally occurring histamine contained in various foods. Histamine intolerance can also involve deficiencies of key enzymes normally produced by the body, such as Diamine Oxidase and Histamine N-Methyl Transferase. This can also be complicated by various genetic mutations.

Mastocytosis is when a person has too many mast cells due to genetic mutations. This can be cutaneous (skin only—also called urticaria pigmentosa) or systemic (in other forms of connective tissue also, especially the stomach and intestinal linings). Cutaneous mastocytosis is diagnosed by skin biopsy, while systemic mastocytosis is diagnosed via bone marrow biopsy.

Mast Cell Activation Syndrome (MCAS) looks very similar to mastocytosis, but in this case the person has a normal number of mast cells. Their mast cells are just hyper-responsive, meaning they release their contents with very little stimulus.

Symptoms and Testing for MCAS

Symptoms common to MCAS include itchiness, easy bruising, lightheaded, diarrhea, intestinal cramping, nausea and vomiting, brain fog, headaches and migraines, fatigue, food and chemical sensitivities.

All symptoms worsen in response to certain triggers, different for each patient, but they tend to be things like high histamine foods, chemical exposure, hormone fluctuations (like before menses), exertion, temperature changes, an stress. Sometimes the triggers are the fillers or additives in medications.

MCAS is determined by meeting three criteria: 1) presenting with the symptoms above, without a diagnosis of systemic mastocytosis or a previous episode of anaphylaxis, 2) increase in serum tryptase (one of the enzymes contained in mast cells—it should be in the cells, not in the bloodstream), or increase in other mast cell mediators like histamine; and 3) improvement with treatment with mast cell stabilizers (mentioned below.)

Causes and Associations of MCAS

MCAS can show up as a concomitant condition with POTS, with Lyme, and with CIRS (Chronic Inflammatory Response Syndrome), a biotoxin-related illness, and possibly one of the most common causes is mold exposure. I also often see symptoms consistent with MCAS associated with multiple chemical sensitivity.

Melanocyte-stimulating hormone (MSH), usually low after exposure to water-damaged buildings, helps to modulate the allergenic immune response when levels are adequate and even causes mast cells to undergo apoptosis, or programmed cell death. The lack of sufficient MSH and histamine's influence on inflammation, in the presence of CIRS, may be part of the reason why CIRS and MCAS are related.

Treatments for MCAS

In addition to a low histamine diet (see below), there are both pharmaceutical and natural approaches. Pharmaceuticals include anti-histamines and anti-leukotrienes, as well as mast cell stabilizers.

Natural mast cell stabilizers include quercetin and Vitamin C. All of these options only "manage" the symptoms.

At the Hansa Center for Optimum Health, our doctors can do sensitive testing of your body using direct resonance testing with the actual human recombinant enzymes, Histamine N-methyl transferase, MAO-A and B, MTHFR, Aldehyde Dehydrogenase,  Diamine oxidase, and others in the metabolism of histamine and inflammatory pathways via Fractal Frequency Modulation to work to enable the restoration of your body's ability to produce these enzymes or help the body blalance them. These tests can identify unique tailored treatments  that can work each biochemical step on the pathways by which histamine gets out of the body. 

I highly suggest getting genetics testing to determine potential problems with these pathways.

Of course, if MCAS is secondary to biotoxin exposure or Multiple Chemical Sensitivity, the real treatment is detoxification and addressing the cause.

Histamine Intolerance Syndrome

There are not many issues that can cause so many problems in virtually every area of the body than Histamine Intolerance (HIT). HIT can be caused by all of the same issues in various degrees as listed above regarding MCAS, especially with the deficiency of the body's production of the primary enzymes.

HIT is a specialty of its own, since there is so much to know. The following are just the bullet points outlining everything you would want to know about HIT.

Histamine Intolerance has been called a "Pseudo-Allergy," because many of its symptoms appear to be allergies when in fact they are not truly IgE-mediated, Type-1 hypersensitivity reactions typically seen in those suffering with allergies.

It is likely that some level of histamine intolerance is aggravating the condition of any person suffering from the many chronic, degenerative or inflammatory illnesses. Without our BRS testing to help guide our doctors, it would be a very difficult quagmire to navigate a person to resolution. Thankfully we can often rapidly find and address many of the possible causes, though it is definitely a lengthy process to dig deep enough to figure out all the various things that have created this systemic issue and how to then facilitate the body's restoration of how it handles histamine.

This article will also provide you with the information of things you need to avoid in your diet, as well as medications, and even natural supplements that might be promoting the overproduction of histamine.

Before you say, "This isn't my problem" please read this article thoroughly and possibly print it out for your doctor so that they can possibly help you.

What is the difference between Allergies and Histamine Intolerance?

• Allergies are an IgE mediated, histamine response to an allergen, i.e., pollen or cat dander.

• Histamine Intolerance (HIT) is a toxic response by the body due to the excessive accumulation of endogenous or exogenous histamine from an inability of the body to efficiently breakdown histamine and hypersensitivity of cell antigen receptors.



Histamine Intolerance is caused by:

– The Over production of Histamine

– The decreased ability of the body to breakdown histamine

• Decreased Diamine Oxidase (DAO) enzyme production in the body

– Histamine is broken down by oxidative deamination by DAO (former name: histaminase)

• Decreased Histamine N-Methyl Transferase (HNMT) enzyme production in the body which is needed to breakdown histamine.

– Histamine is broken down by ring methylation as a result of histamine-N-methyltransferase (HNMT)

See how many systems and symptoms can be caused by HIT

Symptoms of Histamine Intolerance (HIT)

• Histamine serves various functions in our body. This is why histaminosis may trigger a wide range of symptoms, affecting different organ systems.

• People suffering from HIT may display highly diverse symptoms. Every person has individual weak spots, which may be afflicted earlier than other parts in the body. Sufferers may be troubled by many of the following symptoms, either simultaneously or alternately

• Some afflictions are chronic or very frequent, others may only occur sporadically. The symptoms are so varied that the people affected by HIT often do not suspect a single trigger

HIT and Gastro-intestinal and Urinary Symptoms

• The most frequently observed troubles that occur with HIT are acute or chronic gastrointestinal symptoms.

• Irritable stomach or an irritable bowel respectively. A direct connection between food intake and the symptoms is often difficult to discern. This is due to the fact that the ingredients of ingested foods are only slowly absorbed by the body during the bowel transit time, which may last several hours, so that problems may only manifest themselves with a considerable delay.

• Eating aged or leftover foods, or those with high histamine content, may trigger abdominal cramps and severe diarrhea within 15-30 minutes.

• Digestive problems, flatulence, abdominal pain, stitch, stomach or intestinal cramps, frequent or chronic diarrhea, morning diarrhea

• Histamine increases the motility of the bowel movements, so that the bolus passes the intestines faster than normal, which impairs the absorption of nutrients because of the short retention time.

• More rarely also constipation or constipation alternating with diarrhea

• Heart burn, acid reflux (increases HCl)

• Inflammatory gastro-intestinal disorders, irritable bowel syndrome

• Nausea, vomiting

• Frequent and/or painful, burning urination, interstitial cystitis.

• Symptoms similar to gastric flu (gastroenteritis)


HIT and Nervous System Symptoms

• Histamine plays a role in the regulation of the circadian rhythm and acts as neurotransmitter. Histamine stimulates the production of melatonin.

• High levels of histamine (as well as high melatonin) in the body may lead to a wide range of neurological symptoms. Neurological symptoms are in particular pronounced with a HNMT enzymopathy. Headache, fatigue, sleep disturbance may also be typical symptoms of a DAO enzymopathy.

• Headache, migraine, feeling of pressure in the head, dizziness

• Fatigue, loss of energy, lack of motivation, exhaustion

• Insomnia, problems falling asleep or sleeping through the night, only superficial catnapping without deep sleep, dreamlessness

• Lack of concentration, impairment of cognitive performance, slowness

• Tourette's Syndrome

• Noise sensitivity, search for tranquility and uneventfulness, vulnerability for sensory overload

• susceptibility to stress, impaired ability to withstand stress, feeling of burnout (feeling of mental and nervous exhaustion and breakdown)

• Clearing of throat in stress situations

• Tension, nervousness, jumpiness (also without external cause), restlessness, tingling sensation, feeling of caffeine overdose

• Muscle twitching, tremor, clenched jaws, grinding of teeth (bruxism), worn down teeth

• Symptoms similar to those of poisoning with a mild neurotoxin

• Melancholia, sadness, weepiness, depressive moods, depressions (often without visible cause)

• Thoughts of suicide

• Temporary loss or impairment of the sense of smell

• Personality changes, perhaps other mental/neurological disturbances

HIT and Cardiovascular System

• Drop in blood pressure, low blood pressure (hypotension)

• Cardiac arrhythmias

• Palpitation (stronger heart beat caused by a release of adrenaline)

• Racing heart (tachycardia), Postural Orthostatic Tachycardia (POTS)

HIT and Endocrine System

• Altered insulin sensitivity

• Dysmenorrhea (menstrual cramps),

• Amenorrhea

• Endometriosis

• Development disorder, failure to thrive

HIT and Immune System

• Increased susceptibility to infectious diseases, frequent infections

• increased susceptibility for inflammations, inflamed areas

• Sore throat

• Hoarseness

• Flulike symptoms without defined onset of disease, prolonged malaise, pain in the limbs

• Sinus infection (sinusitis): frontal sinusitis, maxillary sinusitis, inflammation of other sinuses such as sphenoid or ethmoid sinuses

• Constant swelling painful lymph nodes

• Tonsillitis, adenoid vegetation (adenoid hyperplasia), possible surgical removal of tonsils. (The tonsils serve the immune defense. Their removal may further acerbate the increased susceptibility for infectious diseases.)

• Lump in one's throat

• Autoimmune illness. Inflammation of connective tissue: tissue underneath the skin with inflammatory pain or tenderness

• Painful feeling of inflammation, heat or pressure in the head, chronic (non-bacterial) inflammation of the brain (chronic encephalitis)

• Painful/burning bladder, desire to void, frequent urination (similar to bacterial bladder infection)

• Conjunctivitis, irritated reddened eyes, itching of the eyes.

• Yellow-white mucus secretions collect in the corners of the eyes.

• Misted, impaired vision

• Inflammatory rheumatic diseases, rheumatoid arthritis (e.g. knuckle joint rheumatism)

• Soft-tissue rheumatism: e.g. pain in the tendons or joints, back pain: the back muscles hurt similar to a strained muscle/muscle ache (muscular rheumatism, inflammation of a muscle)

• Periodic toothache, inflammation of the gums or wisdom teeth

• Herpes simplex labialis (oral herpes, cold sores) or symptoms similar to herpes (e.g. badly healing skin cracks)

HIT and Skin

• Excessive sweating, attack of sweating, night-time sweating, perspiring hands/feet, hot flashes

• Flushing of face following meals (flush), heat build-up, facial skin feels slightly irritated

• Skin blemishes, acne, pimples, blackheads, overproduction of sebaceous gland, oily skin

• Rashes, flushes, itching, eczema, hives (urticaria)

• Atopic eczema, Atopic dermatitis, Itching (e.g. itchy scalp, itchy vaccination scars)

• Physical irritation such as scratching, strokes or heat triggering flashes/rash or itching

• Upper arms covered in little red spots/pimples, partially keratinised or purulent (impaired keratinisation), perhaps in connection with pollen allergies?

• Hands with burning/aching inflammation/blisters/nodules/calluses

• Sun allergy: the skin goes very quickly red in the sun, but the sunburn disappears on the following day.

• Dry lips

HIT and Respiratory Symptoms

• Bronchial Asthma

Perennial rhinitis, swelling of nasal mucous membrane, runny nose (rhinitis, rhinorrhea) especially after food intake, also independent from type and histamine content of food, possibly aggravated by cold/smoke/smog/smells

• Blowing the nose may lead to nosebleed (because of increased permeability of the blood vessels)

• Aphtha lesions of the oral mucosa, which become small yellow-white holes/wounds that hurt and will not heal for days and sometimes months. In addition to the oral mucosa, some papillae on the tongue may hurt like an aphtha.

• Chronic cough, constant tickly throat, dry cough, bronchitis, irritated bronchia

• Constant clearing of the throat, particularly in stress situations

• Sputum: viscid mucus to expectorate, frequent clearing of throat, perhaps also breathy vocal cords, particularly after sumptuous meals (similar to cystic fibrosis)



HIT and Fluid Regulation Symptoms

• Edema (Swelling because of fluid retention in the interstitial tissue)

– Swollen eyelids

– Leg swelling

– Abdominal bloating.

Possible Miscellaneous HIT Symptoms

• Sensitivity to EMF pollution, WiFi, etc.

• Sensitive to Geopathic stressors

• Sensitive to Enviropathic stressors

DAO vs HNMT (The two pathways your body has to break down histamine)

• Diamine Oxidase enzyme (DAO) expression is restricted to specific tissues; the highest activities are shown for small intestines, ascending colon, and for placenta and kidney. DAO is responsible for scavenging extracellular histamine (i.e., after ingestion of histamine-rich food) after mediator release.

• Histamine N-Methyltransferase enzyme (HNMT) is widely expressed in human tissues; the greatest expression is in kidney and liver, followed by spleen, colon, prostate, ovary, spinal cord cells, bronchi, and trachea. HNMT is regarded as the key enzyme for histamine degradation in the bronchial epithelium. HNMT can convert histamine only in the intracellular space of cells.

Sources of Histamine and the cellular release of Histamine

• Foods containing histamine

• Mast cell dysregulation releasing excessive histamine

• Mental/Emotional Stress

• Allergies (endogenous or exogenous antigens)

• Physical stress

• Medications

• Geopathic Stress

• EMF/Enviropathic stress

• Inflammation

Examples of Medications that influence histamine levels

• Non-steroidal anti-inflammatory drugs (ibuprofen)

• Antidepressants (Cymbalta, Effexor, Prozac, Zoloft)

• Immune modulators (Humira, Enbrel, Plaquenil)

• Antiarrhythmics (propanolol, metaprolol, Cardizem, Norvasc)

• Aspirin – Histamine liberator

• Amitriptylene – DAO blocker

• Valium – DAO Blocker

• Lasiks – DAO Blocker

• Codeine – Histamine Liberator

• Augmentin – DAO Blocker

• Chloroquinine – DAO Blocker and Histamine liberator

• Quinine – Histamine liberator

• All X-ray contrast – Histamine liberator

• Metoprin – HNMT blocker

• Opiates (Heroin/Morphine…) – Histamine liberator

• Thiamine/Vit B1 – Histamine liberator

The effect of stress on histamine levels

• Histamine release increases during the periods of panic attack, especially when the adrenergic, “fight or flight” response is at its peak.

• Histamine factors into the fight or flight because H3 histamine receptors in the brain promote the most "wakeful" firing pattern. In fact a sudden rush of histamine in the brain could contribute to a schizophrenic episode.

• Histamine is involved in panic events by causing a closing of the airways in the lungs. When released in the lungs, histamine causes the airways to swell shut in an attempt to close the door on offending allergens and keep them out. Panic attack periods are known for the sense of weight or contraction on the lungs.

Effects of Sleep on Histamine

• Sleep--It has been shown that histaminergic cells have the most "wakeful" firing pattern of any neuronal type. They fire rapidly during waking, and completely stop firing during sleep.

• The cell bodies of neurons which release histamine as a neurotransmitter are found in the posterior hypothalamus, in various tuberomammillary nuclei. From here, these histaminergic neurons project throughout the brain, to the cortex through the medial forebrain bundle.

• Antihistamines, substances that block the H1 histamine receptors improve sleep.

• Destruction of histamine releasing neurons, or inhibition of histamine synthesis leads to an inability to maintain vigilance.

• H3 receptor antagonists (which stimulate histamine release) increase wakefulness.

Influence of Histamine on Sex

• Histamine is released as part of sexual arousal from mast cells in the genitals, and histamine release has been connected to the sex flush in women.

• The female orgasm can be facilitated by supplemental folic acid along with niacin, which will increase histamine release.

• Men with high histamine levels may suffer from premature ejaculations.



Four types of histamine receptors in the body (H1, H2, H3, H4)

H1 Receptors

• Ileum contraction

• Modulate Circadian rhythms

• Itching

• Systemic vasodilation

• Broncho-constriction (allergy-induced asthma)

• pain and itching due to insect stings

• Are the primary receptors involved in allergic rhinitis symptoms and motion sickness.

• Initiates release of intracellular stores of Ca2+ and opens Voltage gated Calcium channels.

H2 Receptors

• speed up sinus rhythms

• Stimulation of gastric acid (HCl) secretion

• Smooth muscle relaxation

• Inhibit antibody synthesis, T-cell proliferation and cytokine production

H3 Receptors

• Decrease Acetylcholine, Serotonin and Norepinephrine neurotransmitter release in Central Nervous System (CNS)

• Presynaptic autoreceptors

H4 Receptors

• Found primarily in bone marrow and white blood cells. It is also expressed in the colon, liver, lung, small intestine, spleen, testes, thymus, tonsils, and trachea.

• Mediate mast cell chemotaxis. Histamine was shown to mediate signaling and chemotaxis of mast cells via the H4 receptor. This mechanism might be responsible for excessive mast cell accumulation in allergen sensitive tissues.

Problems with Antihistamines

• In HIT syndrome, the OTC and prescription antihistamines will cause of worsening of symptoms.

• Most over-the-counter antihistamines only block the H1 and/or H2 receptors

– The excessive histamine is still circulating so it can be forced more to the H3 and H4 receptor pathways

– H3 and H4 receptors are more related to Headaches, nausea, vomiting, vertigo, circadian rhythm problems, arousal, insomnia, appetite issues, memory problems, learning, and body temperature problems.

Methods to address Histamine Intolerance

• Eliminate foods high in Histamine (temporarily or long term)

• BRADE allergy desensitization with NeuroPhotonic Therapy (Available at the Hansa Center only)

• Eliminate medications that block DAO or HNMT, or that liberate histamine from the cells.

• Use BRS to identify remedy support the biochemical pathways to enable the body to produce DAO and/or HNMT.

• Restore probiotics, fecal microbiome transplants.

• Supplement diet with Diamine Oxidase (DAO), such as Hist-DAO (Xymogen)

• Treat Mental/Emotional (HPA axis) stress issues with BRS testing.

• Stabilize IgE mediated prostaglandin activation of mast cell release of histamine. (gamma linolenic Acid…Evening Primrose oil, Borage Oil, Black Currant Seed oil.)

• Oxford University Peptide shots (Amino acid shots) to block the histamine receptors at the cellular level.

Oxford University Peptide Injections

• An antigen must first be attached to cell surface receptors on mast cells. This triggers a response that often includes the release of histamine. Most allergies involve the release of histamine and other pro-inflammatory substances.

• The Oxford Peptides (U.S. = Amino Acid Injections) physically block the receptors so that antigens cannot attach to the cell receptors, therefore no histamine is released by the mast cells.

Antihistamine Supplements 

• Allermac (Jernigan)

• HistDAO (Xymogen)

• HistoCal (NutriWest)

• Resveratrol

• Turmero

• Whole System Histozyme (Nutriwest)

• Total CMO (NW) (autoimmune)

• Phoenix (Dr. Recommends)

• Isopathic Phenolics

• All homeo categories, Dairy, Beautox,

• Vitamin C

• Vitamin E

• Sulfur (MSM)

• Essential fatty acids (GLA)

• Bromelain

• Boswellia (Frankincense)

• Pancreatic enzymes (Digest, Total Enzyme, Carbo-zyme, Amylase)

• R-lipoic acid

• Glucosamine hydrochloride

• Proanthocyanidins (Plant pigments)

• N-Acetyl Cystiene





• Allergic reactions typically have an adrenal component. Cortisol, is a strong anti-inflammatory agent. For this reason proper adrenal function plays an important role in mediating the histamine release and inflammatory reactions that produce the symptoms experienced with allergies.

• A vicious circle occurs with adrenal fatigue and the tendency to having allergies. The more histamine that is released the harder the adrenals have to work to produce more cortisol, thereby the more fatigued the adrenals become, which increases allergic reactions in a vicious circle.

Interactions of Nitric Oxide and Histamine

• Increasing Nitric oxide will down-regulate the release of histamine. (NO Saliva test strips; treat with Neo-40, NOx…)

• Histamine stimulates NO synthesis and release.

• Too much NO increases histamine as the body strives to bring down the high NO. (Be careful when treating low NO that new symptoms are not created by causing the over production of NO.)

• Several factors increase levels of NO in the body: Allergies (histamine), poor iron status, hypoxia (oxygen deficiency), estrogen dominance and Carbon Monoxide exposure.

Dietary Recommendations and Histamine (While eliminating high-histamine foods from your diet is a great idea, diet alone is NOT a long term correction for the underlying HIT problems. You must work with your doctor to correct the enzymatic and histamine metabolic pathways.

• Avoid or reduce eating canned foods and processed or ready made meals.

• Avoid or reduce eating ripened and fermented foods (older cheeses, alcoholic drinks, products containing yeast)

• Histamine levels in foods vary, depending on how ripe, matured or hygienic the foods.

• As much as it is possible, only buy and eat fresh products.

• Don’t allow foods to linger outside the refrigerator – especially meat products

Foods High in Histamine

• Alcohol, primarily wine, champagne and beer

• Pickled or canned foods – sauerkraut. pickles, mayonnaise, olives

• Matured cheeses, including goat cheese

• Cured/Smoked meat products – salami, ham, sausages, bacon, salami, pepperoni, lunch meats and hot dogs

• Shellfish

• Various species of fish: mackerel, mahi-mahi, tuna, anchovies, sardines

• Beans and pulses – chickpeas, soy beans, peanuts

• Nuts – walnuts, cashew nuts, cashews, and peanuts

• Chocolates and other cocoa based products

• Avocados, eggplant, spinach, and tomatoes

• Most citric fruits, apricots, prunes, dates, figs, raisins

• Wheat based products

• Vinegar

• Processed and Ready-made meals

• Salty snacks, sweets with preservatives and artificial colorings

• Soured foods: sour cream, sour milk, buttermilk, sour dough bread

Foods that are Histamine Liberators

• Most citric fruits – kiwi, lemon, lime, pineapple, plums…

• Cocoa and chocolate

• Nuts

• Papaya

• Beans and pulses

• Tomatoes

• Wheat germ

• Additives – benzoate, sulphites, nitrites, glutamate, food dyes

Drinks that are Diamine Oxidase (DAO) Blockers

• Alcohol

• Black tea

• Energy drinks

• Green tea

• Mate tea

Antihistamine Herbs and Spices

• Amaranth seeds

• Anise

• Basil

• Berberine

• Carraway

• Chamomile

• Chili powder

• Cinnamon

• Clove

• Curry powder

• Echinacea

• wild oregano

• Fennel

• Fig

• Ginger

• Ginkgo

• Grapefruit

• Nutmeg

• Passionflower

• Tarragon

• Tumeric

• Skullcap

• Thyme

• Yarrow

• Papaya

• Reishi Mushroom

• Stinging nettle

Foods Low in Histamine

• Freshly cooked meat, poultry (frozen or fresh)

• Freshly caught fish

• Cooked eggs

• Gluten-free grains: rice, quinoa, corn, millet, amaranth

• Fresh fruits: mango, pear, watermelon, apple, kiwi, cantaloupe, grapes

• Fresh vegetables (except tomatoes, spinach, avocado, and eggplant)

• Dairy substitutes: coconut milk, rice milk, hemp milk, almond milk

• Cooking oils: olive oil, coconut oil

• Leafy herbs

• Herbal teas

Effects of Low Histamine (Histopenia)

• Histapenia (Low Histamine): It is found that 30-40 % of people with schizophrenia have low whole blood histamine levels and are over-methylated.

• People with low histamine tend to have more severe mental disorders and hallucinations, paranoid thoughts with less pronounced obsessions, despair, depression, low libido, anxiety, nervous legs and grandiosity.

• People with low histamine often have a multitude of food allergies and environmental allergies but they do not typically have seasonal allergies.

• Approximately 25% of bipolar patients have low histamine levels.

Biochemistry of Histopenia

• Low “Whole blood histamine”

• Low blood zinc

• Low basophils

• Elevated levels of serotonin, dopamine, and norepinephrine.

• Elevated copper, which is a brain stimulant and destroys histamine; causing brain dopamine levels to rise; copper then oxidizes catecholamines such as dopamine thus propagating neurotoxin formation. This causes paranoia and hallucinations in younger individuals, but depression may predominate in the older ones.


Testing for Histamine Intolerance (HIT): (Not all of these test must be performed to diagnose HIT.)

• Histamine Determination, Whole Blood
• Serum quantitative, Diamine Oxidase Activity Test
• Histamine 50-Prick Skin Test
• Serum Tryptase levels are persistently above 15 ng/mL
• 24-hour, Urine histamine metabolite, PGD2
• 11-β-prostaglandin F2 alpha

For over 20 years the Hansa Center for Optimum Health, in Wichita, Kansas has specialized in the restoration of health for people with previously unresponsive and chronic illnesses of virtually all types. Over 85% of people come from other states and countries. If you have done everything you and your doctor know to do and are still struggling, contact our wonderful Patient Care Coordinator, Kara, at patientcare@hansacenter.com, for information on the exciting new treatments we have developed at the Hansa Center for Optimum Health. For additional info, visit our website at www.HansaCenter.com. Call 316-686-5900 ext. 1 to schedule your visit.

This article is for educational purposes. Before implementing any supplements/remedies always consult with your healthcare professional. Due to the complexity of the human condition there remains the possibility of symptoms getting worse. Again, discuss the ideas presented here with your health care professional before beginning, and stop, or get support, if your condition worsens. This information is not intended to treat, cure, diagnose, or mitigate any disease or illness, and has not been evaluated by the FDA. The Hansa Center does not treat named diseases, but seeks to restore the body's optimum structural and functional integrity so that the body can rapidly heal itself. 

*Due to the exhaustive time spent per day with each patient, and poor repayment history of insurance companies, we unfortunately cannot accept insurance assignment. We do participate in Care Credit, and accept all major credit cards. We will gladly accept insurance when our elected officials revamp the health insurance industry to cover all results-based care. We encourage you to vote with this in mind. Please call 316-686-5900 ext. 1, for current pricing for our economically-priced, All-inclusive 2-3 weeks intensive packages of care.

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